WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=23; E=4.93; R=4.67; rawP=1.07e-09; adjP=3.96e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100626 NA GALNTL1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1 57452 ENSG00000100626
2  ENSG00000125877 NA ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 3704 ENSG00000125877
3  ENSG00000083123 NA BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 594 ENSG00000083123
4  ENSG00000130005 NA GAMT guanidinoacetate N-methyltransferase 2593 ENSG00000130005
5  ENSG00000143179 NA UCK2 uridine-cytidine kinase 2 7371 ENSG00000143179
6  ENSG00000164237 NA CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 134147 ENSG00000164237
7  ENSG00000160216 NA AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 56894 ENSG00000160216
8  ENSG00000152556 NA PFKM phosphofructokinase, muscle 5213 ENSG00000152556
9  ENSG00000099810 NA MTAP methylthioadenosine phosphorylase 4507 ENSG00000099810
10  ENSG00000007350 NA TKTL1 transketolase-like 1 8277 ENSG00000007350
11  ENSG00000128311 NA TST thiosulfate sulfurtransferase (rhodanese) 7263 ENSG00000128311
12  ENSG00000112294 NA ALDH5A1 aldehyde dehydrogenase 5 family, member A1 7915 ENSG00000112294
13  ENSG00000151552 NA QDPR quinoid dihydropteridine reductase 5860 ENSG00000151552
14  ENSG00000164398 NA ACSL6 acyl-CoA synthetase long-chain family member 6 23305 ENSG00000164398
15  ENSG00000147408 NA CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 55790 ENSG00000147408
16  ENSG00000162630 NA B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 8707 ENSG00000162630
17  ENSG00000104549 NA SQLE squalene epoxidase 6713 ENSG00000104549
18  ENSG00000075651 NA PLD1 phospholipase D1, phosphatidylcholine-specific 5337 ENSG00000075651
19  ENSG00000033100 NA CHPF2 chondroitin polymerizing factor 2 54480 ENSG00000033100
20  ENSG00000169826 NA CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 55454 ENSG00000169826
21  ENSG00000107242 NA PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 8395 ENSG00000107242
22  ENSG00000106049 NA HIBADH 3-hydroxyisobutyrate dehydrogenase 11112 ENSG00000106049
23  ENSG00000100714 NA MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 4522 ENSG00000100714


Database:KEGG pathway       Name:Arrhythmogenic right ventricular cardiomyopathy (ARVC)       ID:05412
C=74; O=6; E=0.32; R=18.60; rawP=9.17e-07; adjP=1.70e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000130402 NA ACTN4 actinin, alpha 4 81 ENSG00000130402
2  ENSG00000072110 NA ACTN1 actinin, alpha 1 87 ENSG00000072110
3  ENSG00000138795 NA LEF1 lymphoid enhancer-binding factor 1 51176 ENSG00000138795
4  ENSG00000174437 NA ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 488 ENSG00000174437
5  ENSG00000096696 NA DSP desmoplakin 1832 ENSG00000096696
6  ENSG00000165995 NA CACNB2 calcium channel, voltage-dependent, beta 2 subunit 783 ENSG00000165995


Database:KEGG pathway       Name:Glycosaminoglycan biosynthesis - chondroitin sulfate       ID:00532
C=22; O=3; E=0.10; R=31.28; rawP=0.0001; adjP=0.0012
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000033100 NA CHPF2 chondroitin polymerizing factor 2 54480 ENSG00000033100
2  ENSG00000169826 NA CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 55454 ENSG00000169826
3  ENSG00000147408 NA CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 55790 ENSG00000147408


Database:KEGG pathway       Name:Cardiac muscle contraction       ID:04260
C=77; O=4; E=0.34; R=11.92; rawP=0.0004; adjP=0.0037
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000143549 NA TPM3 tropomyosin 3 7170 ENSG00000143549
2  ENSG00000174437 NA ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 488 ENSG00000174437
3  ENSG00000165995 NA CACNB2 calcium channel, voltage-dependent, beta 2 subunit 783 ENSG00000165995
4  ENSG00000105409 NA ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 478 ENSG00000105409


Database:KEGG pathway       Name:Adherens junction       ID:04520
C=73; O=3; E=0.32; R=9.43; rawP=0.0041; adjP=0.0208
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000130402 NA ACTN4 actinin, alpha 4 81 ENSG00000130402
2  ENSG00000072110 NA ACTN1 actinin, alpha 1 87 ENSG00000072110
3  ENSG00000138795 NA LEF1 lymphoid enhancer-binding factor 1 51176 ENSG00000138795


Database:KEGG pathway       Name:Pentose phosphate pathway       ID:00030
C=27; O=2; E=0.12; R=16.99; rawP=0.0062; adjP=0.0208
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000152556 NA PFKM phosphofructokinase, muscle 5213 ENSG00000152556
2  ENSG00000007350 NA TKTL1 transketolase-like 1 8277 ENSG00000007350


Database:KEGG pathway       Name:Dilated cardiomyopathy       ID:05414
C=90; O=3; E=0.39; R=7.65; rawP=0.0073; adjP=0.0208
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000143549 NA TPM3 tropomyosin 3 7170 ENSG00000143549
2  ENSG00000174437 NA ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 488 ENSG00000174437
3  ENSG00000165995 NA CACNB2 calcium channel, voltage-dependent, beta 2 subunit 783 ENSG00000165995


Database:KEGG pathway       Name:Thyroid cancer       ID:05216
C=29; O=2; E=0.13; R=15.82; rawP=0.0071; adjP=0.0208
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000138795 NA LEF1 lymphoid enhancer-binding factor 1 51176 ENSG00000138795
2  ENSG00000143549 NA TPM3 tropomyosin 3 7170 ENSG00000143549


Database:KEGG pathway       Name:Hypertrophic cardiomyopathy (HCM)       ID:05410
C=83; O=3; E=0.36; R=8.29; rawP=0.0058; adjP=0.0208
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000143549 NA TPM3 tropomyosin 3 7170 ENSG00000143549
2  ENSG00000174437 NA ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 488 ENSG00000174437
3  ENSG00000165995 NA CACNB2 calcium channel, voltage-dependent, beta 2 subunit 783 ENSG00000165995


Database:KEGG pathway       Name:Homologous recombination       ID:03440
C=28; O=2; E=0.12; R=16.39; rawP=0.0066; adjP=0.0208
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000197299 NA BLM Bloom syndrome, RecQ helicase-like 641 ENSG00000197299
2  ENSG00000104320 NA NBN nibrin 4683 ENSG00000104320




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).